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KMID : 1059520130570060731
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Journal of the Korean Chemical Society
2013 Volume.57 No. 6 p.731 ~ p.737
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Synthesis, Characterization and Antimicrobial Activity of Bifunctional Sulfonamide-Amide Derivatives
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Abbavaram Babul Reddy A.
Reddyvari Hymavathi R. V.
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Abstract
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A convenient synthesis of bifunctional sulfonamide-amide derivatives was reported. Amide coupling of 4-methyl benzoic acid 1 followed by reaction with chlorosulfonic acid produce ethyl-4-(3-(chlorosulfonyl)-4-methylbenzoyl)piperazine- 1-carboxylate 4. The resulted compound on further treatment with various anilines produces the title sulfonamide-amide derivatives 5a-n. The configurations of these compounds were established by elemental analysis, IR, 1H NMR, mass spectra, and by their preparation from the corresponding 4-methyl benzoic acid 1 and chlorosulfonic acid. All these new compounds demonstrate significant in vitro antibacterial and antifungal activities against all bacterial and fungal strains.
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KEYWORD
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Sulfonamide-amide, 4-Methyl benzoic acid, Chlorosulfonic, Antibacterial and antifungal activities
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